Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Moiseeva, Victoria; Cisneros, Andrés; Sica, Valentina; Deryagin, Oleg; Lai, Yiwei; Jung, Sascha; Andrés, Eva; An, Juan; Segalés, Jessica; Ortet, Laura; Lukesova, Vera; Volpe, Giacomo; Benguría, Alberto; Dopazo, Ana; Benitah, Salvador Aznar; Urano, Yasuteru; Sol, Antonio del; Esteban, Miguel A.; Ohkawa, Yasuyuki; Serrano, Antonio L.; Perdiguero, Eusebio; Muñoz‐Cánoves, Pura

doi:10.1038/s41586-022-05535-x

articleNatureDec 21, 2022HYBRID OA

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

VMVictoria Moiseeva ACAndrés Cisneros VSValentina Sica ODOleg Deryagin YLYiwei Lai

Universitat Pompeu Fabra · Biomedical Research Networking Center on Neurodegenerative Diseases · +19 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Tissue regeneration requires coordination between resident stem cells and local niche cells 1,2 . Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration at all stages of life. The technical limitation of senescent-cell scarcity 3 was overcome by combining single-cell transcriptomics and a senescent-cell enrichment sorting protocol. We identified and isolated different senescent cell types from damaged muscles of young and old mice. Deeper transcriptome, chromatin and pathway analyses revealed conservation of cell identity traits as well as two universal senescence hallmarks (inflammation and fibrosis) across cell type,…

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359

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FWCI: 36.95
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Topics & keywords

Topics

Keywords

Regeneration (biology)
Cell biology
Senescence
Stem cell
Biology
Regenerative medicine
Transcriptome
Inflammation

UN Sustainable Development Goals

Life in Land

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