Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in parallel with new antibiotics, leading to a major global public health crisis over time. Antibiotic resistance may be due to different mechanisms and against different classes of drugs. These mechanisms are usually found in the same organism, giving rise to multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria. One resistance mechanism that is closely associated with the emergence of MDR and XDR bacteria is the efflux of drugs since the same pump can transport different classes of drugs. In Gram-negative bacteria, efflux pumps are present in two configurations: a transmembrane protein anchored in the inner…

• CD
  Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico

  Awards: 2018-4, 424410/2018-4, VPPCB- 07-FIO-18-2-38
• FO
  Fundação Oswaldo Cruz

  Awards: VPPCB-07-FIO-18-2-38, 424410/2018-4, VPPCB- 07-FIO-18-2-38