reviewInternational Journal of Molecular SciencesDec 22, 2022GOLD OA

Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

ILIsma Liza Mohd IsaSLSeong Lin TeohNHNurul Huda Mohd NorSASabarul Afian Mokhtar

National University of Malaysia · Universiti Putra Malaysia

PubMed
Indexed incrossrefpubmed

Abstract

Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back pain (LBP), causing a significant global disability. The IVD consists of an inner core proteoglycan-rich nucleus pulposus (NP) and outer lamellae collagen-rich annulus fibrosus (AF) and is confined by a cartilage end plate (CEP), providing structural support and shock absorption against mechanical loads. Changes to degenerative cascades in the IVD cause dysfunction and instability in the lumbar spine. Various treatments include pharmacological, rehabilitation or surgical interventions that aim to relieve pain; however, these modalities do not halt the pathologic events of disc degeneration or promote tissue…

Citation impact

321
total citations
FWCI
39.85
Percentile
100%
References
105
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Intervertebral disc
  • Medicine
  • Degeneration (medical)
  • Low back pain
  • Back pain
  • Degenerative disc disease
  • Regeneration (biology)
  • Pathology
UN Sustainable Development Goals
  • Good health and well-being
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