reviewBiosensorsDec 27, 2022GOLD OA

Review: 3-Aminopropyltriethoxysilane (APTES) Deposition Methods on Oxide Surfaces in Solution and Vapor Phases for Biosensing Applications

MSMarzhan SypabekovaAHAidan HagemannDRDonggee RhoSKSeunghyun Kim

Baylor University · National NanoFab Center

PubMed
Indexed incrossrefdoajpubmed

Abstract

Surface functionalization and bioreceptor immobilization are critical processes in developing a highly sensitive and selective biosensor. The silanization process with 3-aminopropyltriethoxysilane (APTES) on oxide surfaces is frequently used for surface functionalization because of beneficial characteristics such as its bifunctional nature and low cost. Optimizing the deposition process of the APTES layer to obtain a monolayer is crucial to having a stable surface and effectively immobilizing the bioreceptors, which leads to the improved repeatability and sensitivity of the biosensor. This review provides an overview of APTES deposition methods, categorized into the solution-phase and vapor-phase, and a…

Citation impact

256
total citations
FWCI
28.01
Percentile
100%
References
91
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Silanization
  • Surface modification
  • Biosensor
  • Nanotechnology
  • Deposition (geology)
  • Materials science
  • Monolayer
  • Chemical vapor deposition
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