Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is still a challenging task against the complex intercellular environment. Once synthetic nanoparticles enter the body, they are phagocytosed by immune cells by the immune system. Recently, the cell membrane camouflage strategy has emerged as a novel therapeutic tactic to overcome these issues by utilizing the fundamental properties of natural cells. Macrophage, a type of immune system cells, plays critical roles in various diseases, including cancer, atherosclerosis, rheumatoid arthritis, infection and inflammation, due to the recognition and engulfment function of…

• NN
  National Natural Science Foundation of China

  Awards: 82074129, 2020LZXNYDZ03, 22208269
• SM
  Southwest Medical University

  Awards: 82074129, 2021LZXNYD-J17, 2021ZKZD012