The sirtuin family in health and disease

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory…

• NN
  National Natural Science Foundation of China

  Awards: 81902607, No. 82073647, 82073647, 82102254, 2022YFC2704200
• CM
  China Medical University

  Award: 82102254
• LR
  Liaoning Revitalization Talents Program

  Awards: XLYC1907102, XLYC1802095, No. XLYC1907102
• SH
  Shengjing Hospital