Targeting integrin pathways: mechanisms and advances in therapy

Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals between cells and their environment in a wide range of states in health and diseases. Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational changes, and trafficking. Due to their exposure on the cell surface and sensitivity to the molecular blockade, integrins have been investigated as pharmacological targets for nearly 40 years, but given the complexity of integrins and sometimes opposite…

• PU
  Peking University First Hospital
• NN
  National Natural Science Foundation of China

  Awards: 81903714, No. 81973320, 81973320, 2020YFC2008304, No. 81903714
• MO
  Ministry of Science and Technology of the People's Republic of China

  Award: No. 2020YFC2008304
• PU
  Peking University