Phenotypic signatures of immune selection in HIV-1 reservoir cells
Brigham and Women's Hospital · Ragon Institute of MGH, MIT and Harvard · +4 more institutions
Abstract
Abstract Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite antiretroviral treatment 1,2 but may be vulnerable to host immune responses that could be exploited in strategies to cure HIV-1. Here we used a single-cell, next-generation sequencing approach for the direct ex vivo phenotypic profiling of individual HIV-1-infected memory CD4 + T cells from peripheral blood and lymph nodes of people living with HIV-1 and receiving antiretroviral treatment for approximately 10 years. We demonstrate that in peripheral blood, cells harbouring genome-intact proviruses and large clones of virally infected cells frequently express ensemble signatures of surface markers conferring increased…
Citation impact
- FWCI
- 25.68
- Percentile
- 100%
- References
- 70
Authors
13- WSWeiwei SunCorresponding
Brigham and Women's Hospital, Ragon Institute of MGH, MIT and Harvard
- CGCe Gao
Brigham and Women's Hospital, Ragon Institute of MGH, MIT and Harvard
- CACiputra Adijaya Hartana
Ragon Institute of MGH, MIT and Harvard
- MRMatthew R. Osborn
Ragon Institute of MGH, MIT and Harvard
- KEKevin Einkauf
Brigham and Women's Hospital, Ragon Institute of MGH, MIT and Harvard
Topics & keywords
- Biology
- Immune system
- Phenotype
- Cytotoxic T cell
- Immunology
- Virology
- Gene
- Genetics
- Good health and well-being
Funding
- BABill and Melinda Gates FoundationAwards: AI155233, AI169768, DK120387, INV-002703, AI120008, AI152979, AI130005, AI135940, AI117841
- ATamfAR, The Foundation for AIDS ResearchAwards: 110181-69-RGCV, 110393-72-RPRL
- MGMassachusetts General Hospital
- NINational Institutes of HealthAwards: AI120008, AI135940, DK120387, AI152979, AI155171, AI155233, AI130005, AI164570, 110393-72-RPRL, AI116228, HL134539, AI164562, DA047034, AI169768, AI117841, AI078799
- NCNIH Clinical Center