Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis

Objective Gut microbiota dysbiosis is closely linked to the pathogenesis of rheumatoid arthritis (RA). We aimed to identify potential probiotic gut microbes that can ameliorate the development of RA. Design Microbiota profiling in patients with RA and healthy individuals was investigated via 16S rDNA bacterial gene sequencing and shotgun metagenomics. Collagen-induced arthritic mice and TNF-α transgenic mice were used to evaluate the roles of the gut commensal Parabacteroides distasonis in RA. The effects of P. distasonis -derived microbial metabolites on the differentiation of CD4 + T cells and macrophage polarisation were also investigated. Results The relative abundance of P. distasonis in new-onset…

• NN
  National Natural Science Foundation of China

  Award: 82170424, 82174098, 81803694 and 81700364
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20170179 and BK20161573