reviewCellsJan 3, 2023GOLD OA

Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SWStephen WoodTMTimothy M. KuzelSHSasha H. Shafikhani

Rush University Medical Center

PubMed
Indexed incrossrefdoajpubmed

Abstract

Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes P. aeruginosa a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. In this review, we review the important acute and chronic infections caused by this pathogen. We next discuss various animal models which have been developed to evaluate P. aeruginosa pathogenesis and assess therapeutics against this pathogen. Next, we review current treatments (antibiotics and vaccines) and provide an overview of their efficacies and their limitations. Finally, we…

Citation impact

224
total citations
FWCI
20.28
Percentile
100%
References
479
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Pseudomonas aeruginosa
  • Microbiology
  • Animal model
  • Biology
  • Medicine
  • Bacteria
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding