articleACS SensorsJan 9, 2023Closed access

Photocurrent-Polarity-Switching Photoelectrochemical Biosensor for Switching Spatial Distance Electroactive Tags

RZRuijin ZengJXJianhui XuTLTikai LiangMLMei‐Jin LiDTDianping Tang

Fuzhou University

PubMed
Indexed incrossrefpubmed

Abstract

This work presents a photocurrent-polarity-switching-based photoelectrochemical (PEC) biosensing platform for ultrasensitive detection of microRNA-21 (miR-21) through target-triggered catalytic hairpin assembly (CHA) for modulation of methylene blue (MB) and ferrocene (Fc) positional configurations using double-shelled Cu-doped ZnS nanocages (NCs)-Au nanoparticles (NPs) as photoactive materials. In the presence of miR-21, the assembly of MB-labeled HP1 and Fc-labeled HP2 leads to the generation of a large amount of double-stranded DNA (HP1-HP2), which pushes MB away from the electrode surface and brings Fc close to the electrode surface, resulting in effectively quenching the enhanced PEC signal to activate…

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207
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Authors

5

Topics & keywords

Topics
Keywords
  • Photocurrent
  • Biosensor
  • Polarity (international relations)
  • Materials science
  • Optoelectronics
  • Electrode
  • Photoelectrochemistry
  • SIGNAL (programming language)
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