reviewCancer DiscoveryJan 9, 2023BRONZE OA

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

CFChiara FalcomatàSBStefanie BärthelGSGünter SchneiderRRRoland RadMSMarc Schmidt‐Supprian

German Cancer Research Center · Heidelberg University · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Immunotherapies have shown benefits across a range of human cancers, but not pancreatic ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive tumor microenvironment (TME) constitutes an important roadblock to their efficacy. The landscape of the TME differs substantially across PDAC subtypes, indicating context-specific principles of immunosuppression. In this review, we discuss how PDAC cells, the local TME, and systemic host and environmental factors drive immunosuppression in context. We argue that unraveling the mechanistic drivers of the context-specific modes of immunosuppression will open new possibilities to target PDAC more efficiently by using multimodal…

Citation impact

180
total citations
FWCI
38.86
Percentile
100%
References
185
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Context (archaeology)
  • Pancreatic cancer
  • Tumor microenvironment
  • Cancer
  • Cancer research
  • Computational biology
  • Biology
  • Medicine
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