Immune Exosomes Loading Self-Assembled Nanomicelles Traverse the Blood–Brain Barrier for Chemo-immunotherapy against Glioblastoma

Effective drug delivery and prevention of postoperative recurrence are significant challenges for current glioblastoma (GBM) treatment. Poor drug delivery is mainly due to the presence of the blood-brain barrier (BBB), and postoperative recurrence is primarily due to the resistance of GBM cells to chemotherapeutic drugs and the presence of an immunosuppressive microenvironment. Herein, a biomimetic nanodrug delivery platform based on endogenous exosomes that could efficiently target the brain without targeting modifications and co-deliver pure drug nanomicelles and immune adjuvants for safe and efficient chemo-immunotherapy against GBM is prepared. Inspired by the self-assembly technology of small molecules,…

• CA
  China Association for Science and Technology

  Award: 2021-QNRC2-A01
• NN
  National Natural Science Foundation of China

  Awards: 82274104, 82074024, 81903557
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20190802
• NU
  Nanjing University of Chinese Medicine

  Awards: NZY81903557, 2020YLXK019