Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis
Shanghai Medical College of Fudan University · Sun Yat-sen University · +6 more institutions
Abstract
Sepsis is a persistent systemic inflammatory condition involving multiple organ failures resulting from a dysregulated immune response to infection, and one of the hallmarks of sepsis is endothelial dysfunction. During its progression, neutrophils are the first line of innate immune defence against infection. Aside from traditional mechanisms, such as phagocytosis or the release of inflammatory cytokines, reactive oxygen species and other antibacterial substances, activated neutrophils also release web-like structures composed of tangled decondensed DNA, histone, myeloperoxidase and other granules called neutrophil extracellular traps (NETs), which can efficiently ensnare bacteria in the circulation. In…
Citation impact
- FWCI
- 54.85
- Percentile
- 100%
- References
- 167
Authors
7- HZHao ZhangCorresponding
Shanghai Medical College of Fudan University, Sun Yat-sen University, Fudan University, Environmental Protection Engineering (Greece), Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University
- YWYanghanzhao Wang
Shanghai Medical College of Fudan University, Sun Yat-sen University, Fudan University, Environmental Protection Engineering (Greece), Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University
- MQMengdi Qu
Shanghai Medical College of Fudan University, Sun Yat-sen University, Fudan University, Environmental Protection Engineering (Greece), Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University
- WLWenqian Li
Sun Yat-sen University, Fudan University, Environmental Protection Engineering (Greece), Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University
- DWDan Wu
Shanghai Medical College of Fudan University, Sun Yat-sen University, Fudan University, Environmental Protection Engineering (Greece), Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University
Topics & keywords
- Neutrophil extracellular traps
- Sepsis
- Innate immune system
- Immunology
- Endothelial dysfunction
- Inflammation
- Endothelium
- Glycocalyx