Extracellular Vesicles: New Classification and Tumor Immunosuppression

Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles carrying various types of molecules. These EV cargoes are often used as pathophysiological biomarkers and delivered to recipient cells whose fates are often altered in local and distant tissues. Classical EVs are exosomes, microvesicles, and apoptotic bodies, while recent studies discovered autophagic EVs, stressed EVs, and matrix vesicles. Here, we classify classical and new EVs and non-EV nanoparticles. We also review EVs-mediated intercellular communication between cancer cells and various types of tumor-associated cells, such as cancer-associated fibroblasts, adipocytes, blood vessels, lymphatic vessels, and immune cells. Of note,…

• WS
  Wesco Science Foundation
• JS
  Japan Society for the Promotion of Science

  Awards: 20K09904, 20K09904-CS, 22F22409, 19H03817, 20H03888, 21K08902, 21K08902-HY, 20H03888-HN, 22H03511, 19H03817-MT, 20K20611