TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis

Abstract Sepsis-induced cardiomyopathy (SICM) is common in septic patients with a high mortality and is characterized by an abnormal immune response. Owing to cellular heterogeneity, understanding the roles of immune cell subsets in SICM has been challenging. Here we identify a unique subpopulation of cardiac-resident macrophages termed CD163 + RETNLA + (Mac1), which undergoes self-renewal during sepsis and can be targeted to prevent SICM. By combining single-cell RNA sequencing with fate mapping in a mouse model of sepsis, we demonstrate that the Mac1 subpopulation has distinct transcriptomic signatures enriched in endocytosis and displays high expression of TREM2 (TREM2 hi ). TREM2 hi Mac1 cells actively…

• SR
  Sir Run Run Shaw Hospital
• NN
  National Natural Science Foundation of China

  Awards: 92049108, 82230074, 82072221, 81720108025, 81971809
• ZU
  Zhejiang University
• NK
  National Key Research and Development Program of China

  Awards: 2017YFE0196600, 2018YFC2001904
• IO
  Institute of Genetics
• NS
  Natural Science Foundation of Zhejiang Province

  Award: LZ22H150002