reviewInternational Journal of Molecular SciencesJan 12, 2023GOLD OA

Pathophysiology of Inflammatory Bowel Disease: Innate Immune System

ÁSÁngela SaézBHBeatriz Herrero‐FernándezRGRaquel Gómez-BrisHSHector Sánchez-MartinezJMJosé María González

Universidad Francisco de Vitoria · Research Institute Hospital 12 de Octubre · +4 more institutions

PubMed
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Abstract

Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause. Intestinal innate immunity is enacted by neutrophils, monocytes, macrophages, and dendritic cells (DCs), and innate lymphoid cells and NK cells, characterized by their capacity to produce a rapid and nonspecific reaction as a first-line response. Innate immune cells (IIC) defend against pathogens and excessive entry of intestinal microorganisms, while preserving immune tolerance to resident intestinal microbiota. Changes to this equilibrium are linked to intestinal inflammation in the gut and IBD. IICs mediate host defense…

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5

Topics & keywords

Topics
Keywords
  • Innate immune system
  • Immune system
  • Immunology
  • Innate lymphoid cell
  • CCL18
  • Inflammation
  • Acquired immune system
  • Inflammatory bowel disease
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