The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
East China University of Science and Technology · Chinese Academy of Sciences · +9 more institutions
Abstract
Cancer remains as one of the most significant health problems, with approximately 19 million people diagnosed worldwide each year. Chemotherapy is a routinely used method to treat cancer patients. However, current treatment options lack the appropriate selectivity for cancer cells, are prone to resistance mechanisms, and are plagued with dose-limiting toxicities. As such, researchers have devoted their attention to developing prodrug-based strategies that have the potential to overcome these limitations. This tutorial review highlights recently developed prodrug strategies for cancer therapy. Prodrug examples that provide an integrated diagnostic (fluorescent, photoacoustic, and magnetic resonance imaging)…
Citation impact
- FWCI
- 27.98
- Percentile
- 100%
- References
- 162
Authors
11- HHHai‐Hao Han
East China University of Science and Technology, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences
- HWHan-Min Wang
Chinese Academy of Sciences, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences
- PJParamesh Jangili
Korea University
- MLMingle Li
Korea University
- LWLuling WuCorresponding
University of Bath
Topics & keywords
- Prodrug
- Cancer therapy
- Combinatorial chemistry
- Chemistry
- Cancer
- Nanotechnology
- Medicine
- Pharmacology
Funding
- NSNational Science FoundationAwards: 2020ZD01, 21JC1406600, 21XD1404600
- NSNatural Science Foundation of ShanghaiAwards: 21XD1404600, 21JC1406600, 22140901000
- HNHenan Normal UniversityAward: 2020ZD01
- RSRoyal Society
- UOUniversity of Oxford
- UOUniversity of BathAward: 2020ZD01
- NRNational Research FoundationAward: 2019M3E5D1A01068998
- NNNational Natural Science Foundation of ChinaAwards: 82130099, 21788102, 22107029, 31871414, 81971265, B16017, 17520750100, 82151219, 9185920077, 2018SHZDZX03, 2020ZD01, 91853201
- CPChina Postdoctoral Science FoundationAwards: 2020M681196, No. 2020M681196, 21788102
- SAScience and Technology Commission of Shanghai MunicipalityAwards: 21788102, 2018SHZDZX0, 22ZR1415200, 21XD1404600, B16017, 2018SHZDZX03, 17520750100
- NRNational Research Foundation of KoreaAwards: 2020H1D3A1A02080172, 2019M3E5D1A01068998
- CSChina Scholarship Council
- MOMinistry of Science and ICT, South KoreaAwards: 2018R1A3B1052702, 2019M3E5D1A01068998
- JCJesus College, University of Cambridge
- JCJesus College, University of Oxford
- FRFundamental Research Funds for the Central UniversitiesAwards: 2018SHZDZX03, 21788102, B16017, 17520750100, 222201717003