Pathophysiology of obesity and its associated diseases
Qingdao National Laboratory for Marine Science and Technology · Ocean University of China · +3 more institutions
Abstract
The occurrence of obesity has increased across the whole world. Many epidemiological studies have indicated that obesity strongly contributes to the development of cancer, cardiovascular diseases, type 2 diabetes, liver diseases and other disorders, accounting for a heavy burden on the public and on health-care systems every year. Excess energy uptake induces adipocyte hypertrophy, hyperplasia and formation of visceral fat in other non-adipose tissues to evoke cardiovascular disease, liver diseases. Adipose tissue can also secrete adipokines and inflammatory cytokines to affect the local microenvironment, induce insulin resistance, hyperglycemia, and activate associated inflammatory signaling pathways. This…
Citation impact
- FWCI
- 85.97
- Percentile
- 100%
- References
- 379
Authors
8- XJXin Jin
Qingdao National Laboratory for Marine Science and Technology, Ocean University of China
- TQTingting Qiu
Qingdao National Laboratory for Marine Science and Technology, Ocean University of China
- LLLi Li
Qingdao National Laboratory for Marine Science and Technology, Ocean University of China
- RYRilei Yu
Qingdao National Laboratory for Marine Science and Technology, Ocean University of China
- XCXiguang Chen
Ocean University of China
Topics & keywords
- Obesity
- Adipokine
- Adipose tissue
- Medicine
- Insulin resistance
- Fatty liver
- Disease
- Diabetes mellitus
- Good health and well-being