Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing
Blood Center of Zhejiang Province · Second Affiliated Hospital of Zhejiang University · +3 more institutions
Abstract
Tendon-bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator cuff injury, are the most common soft tissue injuries. In most situations, surgical tendon/ligament reconstruction is necessary for treating such injuries. However, a significant number of cases failed because healing of the enthesis occurs through scar tissue formation rather than the regeneration of transitional tissue. In recent years, the therapeutic potential of mesenchymal stem cells (MSCs) has been well documented in animal and clinical studies, such as chronic paraplegia, non-ischemic heart failure, and osteoarthritis of the knee. MSCs are multipotent stem cells, which have self-renewability and the ability to…
Citation impact
- FWCI
- 65.93
- Percentile
- 100%
- References
- 134
Authors
11- JZJiaxuan Zou
Blood Center of Zhejiang Province, Second Affiliated Hospital of Zhejiang University, Zhejiang University
- WYWeinan Yang
Blood Center of Zhejiang Province, Second Affiliated Hospital of Zhejiang University, Zhejiang University
- WCWushi Cui
Blood Center of Zhejiang Province, Second Affiliated Hospital of Zhejiang University, Zhejiang University
- CLCongsun Li
Blood Center of Zhejiang Province, Second Affiliated Hospital of Zhejiang University, Zhejiang University
- CMChiyuan Ma
Blood Center of Zhejiang Province, Second Affiliated Hospital of Zhejiang University, Zhejiang University
Topics & keywords
- Mesenchymal stem cell
- Microvesicles
- Regenerative medicine
- Stem cell
- Bone healing
- Tendon
- Wound healing
- Chemistry