Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

Autophagy is a conserved lysosomal degradation pathway where cellular components are dynamically degraded and re-processed to maintain physical homeostasis. However, the physiological effect of autophagy appears to be multifaced. On the one hand, autophagy functions as a cytoprotective mechanism, protecting against multiple diseases, especially tumor, cardiovascular disorders, and neurodegenerative and infectious disease. Conversely, autophagy may also play a detrimental role via pro-survival effects on cancer cells or cell-killing effects on normal body cells. During disorder onset and progression, the expression levels of autophagy-related regulators and proteins encoded by autophagy-related genes (ATGs) are…

• NN
  National Natural Science Foundation of China

  Awards: 82272388, 82273566, 82072365
• UO
  University of Science and Technology of China
• NS
  Natural Science Foundation of Anhui Province

  Award: 2008085MH241
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2019A1515011666