Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges

Choi, Wonseok; Park, Byullee; Choi, Seongwook; Oh, Donghyeon; Kim, Jongbeom; Kim, Chulhong

doi:10.1021/acs.chemrev.2c00627

reviewChemical ReviewsJan 16, 2023Closed access

Recent Advances in Contrast-Enhanced Photoacoustic Imaging: Overcoming the Physical and Practical Challenges

WCWonseok Choi BPByullee Park SCSeongwook Choi DODonghyeon Oh JKJongbeom Kim

Pohang University of Science and Technology

PubMed

Indexed incrossrefpubmed

Abstract

For decades now, photoacoustic imaging (PAI) has been investigated to realize its potential as a niche biomedical imaging modality. Despite its highly desirable optical contrast and ultrasonic spatiotemporal resolution, PAI is challenged by such physical limitations as a low signal-to-noise ratio (SNR), diminished image contrast due to strong optical attenuation, and a lower-bound on spatial resolution in deep tissue. In addition, contrast-enhanced PAI has faced practical limitations such as insufficient cell-specific targeting due to low delivery efficiency and difficulties in developing clinically translatable agents. Identifying these limitations is essential to the continuing expansion of the field, and…

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Topics & keywords

Topics

Keywords

Photoacoustic imaging in biomedicine
Contrast (vision)
Modality (human–computer interaction)
Optical imaging
Image contrast
Resolution (logic)
Computer science
Nanotechnology

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