ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury
Tongji Hospital · Huazhong University of Science and Technology
Abstract
Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent hyperglycemia play an essential role in cardiotoxicity. To clarify whether cuproptosis was involved in AGEs-induced cardiotoxicity, we analyzed the toxicity of AGEs and copper in AC16 cardiomyocytes and in STZ-induced or db/db-diabetic mouse models. The results showed that copper ionophore elesclomol induced cuproptosis in cardiomyocytes. It was only rescued by copper chelator tetrathiomolybdate rather than by other cell death inhibitors. Intriguingly, AGEs triggered cardiomyocyte death and aggravated it when incubated with CuCl2 or…
Citation impact
- FWCI
- 30.93
- Percentile
- 100%
- References
- 51
Authors
13- SHShengqi Huo
Tongji Hospital, Huazhong University of Science and Technology
- QWQian Wang
Tongji Hospital, Huazhong University of Science and Technology
- WSWei Shi
Tongji Hospital, Huazhong University of Science and Technology
- LPLulu Peng
Tongji Hospital, Huazhong University of Science and Technology
- YJYue Jiang
Tongji Hospital, Huazhong University of Science and Technology
Topics & keywords
- Downregulation and upregulation
- Cardiotoxicity
- Diabetic cardiomyopathy
- Cell biology
- Mitochondrion
- Advanced glycation end-product
- Internal medicine
- Chemistry
- Good health and well-being