Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Chinese Center For Disease Control and Prevention · Zhengzhou University · +1 more institution
Abstract
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in human health. An altered microbiome can be associated with complex diseases. Intratumoral microbial components are found in multiple tumor tissues and are closely correlated with cancer initiation and development and therapy efficacy. The intratumoral microbiota may contribute to promotion of the initiation and progression of cancers by DNA mutations, activating carcinogenic pathways, promoting chronic inflammation, complement system, and initiating metastasis. Moreover, the intratumoral microbiota may not only enhance antitumor immunity via mechanisms including STING signaling activation, T and NK cell activation,…
Citation impact
- FWCI
- 97.48
- Percentile
- 100%
- References
- 250
Authors
4- YLYang LiCorresponding
Chinese Center For Disease Control and Prevention, Zhengzhou University, First Affiliated Hospital of Zhengzhou University
- ALAitian Li
First Affiliated Hospital of Zhengzhou University
- YWYing Wang
First Affiliated Hospital of Zhengzhou University
- YZYi Zhang
Chinese Center For Disease Control and Prevention, Zhengzhou University, First Affiliated Hospital of Zhengzhou University
Topics & keywords
- Immune system
- Cancer research
- Cancer
- Microbiome
- Biology
- Immunology
- Crosstalk
- Dysbiosis
- Good health and well-being