reviewJournal of Controlled ReleaseJan 19, 2023HYBRID OA

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

University of Nigeria · Enugu State University of Science and Technology · +1 more institution

PubMed
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Abstract

Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a significant challenge to efficiently deliver drugs to the eye through this route because of various structural and physiological constraints that restrict the distribution of therapeutic molecules into the ocular tissues. The bioavailability of topically applied ocular medications such as eye drops is typically less than 5%. Developing novel delivery systems to increase the retention time on the ocular surfaces and…

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