reviewAngewandte Chemie International EditionJan 17, 2023Closed access

A Forward Vision for Chemodynamic Therapy: Issues and Opportunities

PZPeiran ZhaoHLHuiyan LiWBWenbo Bu

Fudan University

PubMed
Indexed incrossrefpubmed

Abstract

Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in the field of chemodynamic therapy (CDT). However, the exact mechanism of CDT is obscured by the unique tumor chemical environment and inevitable nanoparticle-cell interactions, thus impeding further development. In this Scientific Perspective, the significance of CDT is clarified, the complex mechanism is deconstructed into primitive chemical and biological interactions, and the mechanism research directions based on the chemical kinetics and biological signaling pathways are discussed in detail. Moreover, beneficial outlooks are presented to enlighten the evolution of next-generation CDT.…

Citation impact

285
total citations
FWCI
29.71
Percentile
100%
References
106
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Nanomedicine
  • Mechanism (biology)
  • Perspective (graphical)
  • Cancer therapy
  • Field (mathematics)
  • Nanotechnology
  • Computer science
  • Chemistry
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