Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity

Andrés, Celia María Curieses; Lastra, José Manuel Pérez de la; Andrés, Celia; Plou, Francisco J.; Pérez‐Lebeña, Eduardo

doi:10.3390/ijms24031841

reviewInternational Journal of Molecular SciencesJan 17, 2023GOLD OA

Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity

CMCelia María Curieses Andrés JMJosé Manuel Pérez de la Lastra CACelia Andrés FJFrancisco J. Plou EPEduardo Pérez‐Lebeña

Hospital Clínico Universitario de Valladolid · Instituto de Productos Naturales y Agrobiología · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At the physiological balance level, they are a by-product of O2 reduction, necessary for cell signalling, and at the pathological level they are considered harmful, as they can induce disease and apoptosis, necrosis, ferroptosis, pyroptosis and autophagic cell death. This revision focuses on understanding the main characteristics of the superoxide O2•−, its generation pathways, the biomolecules it oxidizes and how it may contribute to their modification and toxicity. The role of superoxide dismutase, the enzyme responsible for the removal of most of the superoxide produced in living organisms, is studied. At the same time, the…

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300

total citations

FWCI: 46.64
Percentile: 100%
References: 238

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Authors

5

Topics & keywords

Topics

Keywords

Superoxide
Innate immune system
Chemistry
Immunity
Core (optical fiber)
Biochemistry
Immunology
Biology

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