Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population
Laboratory of Data Discovery for Health · University of Hong Kong · +8 more institutions
Abstract
The SARS-CoV-2 Omicron variant has demonstrated enhanced transmissibility and escape of vaccine-derived immunity. Although first-generation vaccines remain effective against severe disease and death, robust evidence on vaccine effectiveness (VE) against all Omicron infections, irrespective of symptoms, remains sparse. We used a community-wide serosurvey with 5,310 subjects to estimate how vaccination histories modulated risk of infection in infection-naive Hong Kong during a large wave of Omicron BA.2 epidemic in January-July 2022. We estimated that Omicron infected 45% (41-48%) of the local population. Three and four doses of BNT162b2 or CoronaVac were effective against Omicron infection 7 days after…
Citation impact
- FWCI
- 37.57
- Percentile
- 100%
- References
- 74
Authors
20- JJJonathan J. LauCorresponding
Laboratory of Data Discovery for Health, University of Hong Kong
- SMSamuel M. S. Cheng
University of Hong Kong
- KLKathy Leung
University of Hong Kong - Shenzhen Hospital, Laboratory of Data Discovery for Health, University of Hong Kong
- CKCheuk Kwong Lee
- AHAsmaa Hachim
HKU-Pasteur Research Pole, University of Hong Kong
Topics & keywords
- Vaccination
- Coronavirus disease 2019 (COVID-19)
- Medicine
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Population
- Transmissibility (structural dynamics)
- Immunization
- Virology
- Good health and well-being