The person-to-person transmission landscape of the gut and oral microbiomes

Abstract The human microbiome is an integral component of the human body and a co-determinant of several health conditions 1,2 . However, the extent to which interpersonal relations shape the individual genetic makeup of the microbiome and its transmission within and across populations remains largely unknown 3,4 . Here, capitalizing on more than 9,700 human metagenomes and computational strain-level profiling, we detected extensive bacterial strain sharing across individuals (more than 10 million instances) with distinct mother-to-infant, intra-household and intra-population transmission patterns. Mother-to-infant gut microbiome transmission was considerable and stable during infancy (around 50% of the same…

• SF
  Simons Foundation
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca

  Awards: H2020, RBFR13EWWI_001
• UD
  Università degli Studi di Trento
• NI
  National Institutes of Health

  Awards: 1U01CA230551, H2020
• H2
  Horizon 2020 Framework Programme

  Awards: 818368, ONCOBIOME-825410 project, ONCOBIOME-825410, MASTER-818368 project, 964590, 825410
• MR
  Medical Research Council

  Awards: MR/S005013/1, MR/N01183X/1
• NC
  National Cancer Institute

  Award: 1U01CA230551