The role of autophagy in viral infections
Huazhong Agricultural University · Center of Hubei Cooperative Innovation for Emissions Trading System
Abstract
Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral functions during a viral invasion. However, co-evolution and co-adaptation between viruses and autophagy have armed viruses with multiple strategies to subvert the autophagic machinery and counteract cellular antiviral responses. Specifically, the host cell quickly initiates the autophagy to degrade virus particles or virus components upon a viral infection, while cooperating with anti-viral interferon response to inhibit the virus replication. Degraded virus-derived antigens can be presented to T lymphocytes to orchestrate the adaptive immune response. Nevertheless, some viruses have evolved the ability to inhibit…
Citation impact
- FWCI
- 38.76
- Percentile
- 100%
- References
- 258
Authors
6- TCTong ChenCorresponding
Huazhong Agricultural University, Center of Hubei Cooperative Innovation for Emissions Trading System
- STShaoyu Tu
Huazhong Agricultural University, Center of Hubei Cooperative Innovation for Emissions Trading System
- LDLing Ding
Huazhong Agricultural University, Center of Hubei Cooperative Innovation for Emissions Trading System
- MJMeilin Jin
Huazhong Agricultural University, Center of Hubei Cooperative Innovation for Emissions Trading System
- HCHuanchun Chen
Huazhong Agricultural University, Center of Hubei Cooperative Innovation for Emissions Trading System
Topics & keywords
- Autophagy
- Virology
- Biology
- Computational biology
- Genetics
- Apoptosis