reviewCancersJan 18, 2023GOLD OA

The Current Status of Photodynamic Therapy in Cancer Treatment

Shenzhen University · Shenzhen Luohu People's Hospital · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic therapy (PDT), a non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance in cancer therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well as oxygen dependence, largely limit its therapeutic efficiency for solid tumors treatment. Thus, numerous strategies have gone into overcoming these obstacles, such as exploring new photosensitizers with higher photodynamic conversion efficiency, alleviating tumor hypoxia to fuel the…

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