Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Harvard University · Center for Systems Biology · +2 more institutions
Abstract
Advanced solid cancers are complex assemblies of tumor, immune, and stromal cells characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D reconstruction, spatial statistics, and machine learning to identify cell types and states underlying morphological features of known diagnostic and prognostic significance in colorectal cancer. Quantitation of these features in high-plex marker space reveals recurrent transitions from one tumor morphology to the next, some of which are coincident with long-range gradients in the expression of oncogenes and epigenetic regulators. At the tumor invasive margin, where tumor, normal, and immune cells compete, T cell suppression involves…
Citation impact
- FWCI
- 38.79
- Percentile
- 100%
- References
- 97
Authors
11- JLJia‐Ren Lin
Harvard University, Center for Systems Biology
- SWShu Wang
Harvard University, Center for Systems Biology
- SCShannon Coy
Brigham and Women's Hospital, Harvard University, Center for Systems Biology
- YCYu‐An Chen
Harvard University, Center for Systems Biology
- CYClarence Yapp
Harvard University, Center for Systems Biology
Topics & keywords
- Biology
- Epigenetics
- Stromal cell
- Immune system
- Colorectal cancer
- Phenotype
- Cancer
- Cancer research
- Good health and well-being