Nanoparticle protein corona: from structure and function to therapeutic targeting

. Since the function of a protein is closely connected to its folded structure, slight differences in the surrounding environment as well as the surface characteristics of the NP materials may cause proteins to lose or gain a function. As a result, this can alter the downstream functionality of the NPs. This review introduces the main biological factors affecting the conformation of proteins associated with the PC. Then, four types of NPs with extensive utility in biomedical applications are described in greater detail, focusing on the conformation and orientation of adsorbed proteins. This is followed by a discussion on the instances in which the conformation of adsorbed proteins can be leveraged for…

• NS
  National Science Foundation

  Awards: CBET-2145491, 1845298, CAREER, 2145491
• BW
  Burroughs Wellcome Fund
• TU
  Temple University
• NI
  National Institutes of Health

  Awards: NIDDK R01 DK123049, DP2 TR002776, R01 DK123049, NCI R01 CA241661, NCI R01, NCI R37 CA244911, NIDDK R01
• NO
  NIH Office of the Director

  Award: DP2 TR002776
• NC
  National Cancer Institute

  Awards: R37 CA244911, R01 CA241661
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: R01 DK123049
• NI
  National Institute of Dental and Craniofacial Research

  Award: T90DE030854
• DO
  Division of Chemical, Bioengineering, Environmental, and Transport Systems

  Awards: CBET-2145491, 2145491