Lymphatic vessels in bone support regeneration after injury
University of Oxford · MRC Weatherall Institute of Molecular Medicine · +7 more institutions
Abstract
Blood and lymphatic vessels form a versatile transport network and provide inductive signals to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and hematopoiesis, but current dogma suggests that bone lacks lymphatic vessels. Here, by combining high-resolution light-sheet imaging and cell-specific mouse genetics, we demonstrate presence of lymphatic vessels in mouse and human bones. We find that lymphatic vessels in bone expand during genotoxic stress. VEGF-C/VEGFR-3 signaling and genotoxic stress-induced IL6 drive lymphangiogenesis in bones. During lymphangiogenesis, secretion of CXCL12 from proliferating lymphatic endothelial cells is critical for hematopoietic and bone…
Citation impact
- FWCI
- 43.30
- Percentile
- 100%
- References
- 93
Authors
11- LBLincoln Biswas
University of Oxford, MRC Weatherall Institute of Molecular Medicine, MRC Human Immunology Unit
- JCJunyu Chen
Sichuan University, University of Oxford, MRC Weatherall Institute of Molecular Medicine, MRC Human Immunology Unit, State Key Laboratory of Oral Diseases
- JDJessica De Angelis
University of Oxford, MRC Weatherall Institute of Molecular Medicine, MRC Human Immunology Unit
- ASAmit Singh
Heidelberg University, University of Oxford, MRC Weatherall Institute of Molecular Medicine, MRC Human Immunology Unit
- COCharlotte Owen-Woods
University of Oxford, MRC Weatherall Institute of Molecular Medicine, MRC Human Immunology Unit
Topics & keywords
- Lymphangiogenesis
- Lymphatic system
- Biology
- Regeneration (biology)
- Lymphatic Endothelium
- Haematopoiesis
- Lymphatic vessel
- Bone marrow
Funding
- ASAmerican Society for Bone and Mineral Research
- NINational Institute for Health and Care Research
- RSRoyal SocietyAward: RG170326
- UOUniversity of Oxford
- MRMedical Research CouncilAwards: MCU_12010/10, MR/P02209X/1, MR/P02209X/1
- EREuropean Research CouncilAwards: 805201, 2017/JGF/001
- JFJohn Fell Fund, University of OxfordAwards: 161/061, 202300/Z/16/Z