Acetyl-CoA metabolism in cancer

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the tricarboxylic acid cycle and is the essential building block for fatty acid and isoprenoid biosynthesis. It also functions as a signalling metabolite as the substrate for lysine acetylation reactions, enabling the modulation of protein functions in response to acetyl-CoA availability. Recent years have seen exciting advances in our understanding of acetyl-CoA metabolism in normal physiology and in cancer, buoyed by new mouse models, in vivo stable-isotope tracing approaches and improved methods for measuring acetyl-CoA, including in…

• NI
  National Institutes of Health

  Awards: R01CA228339, R01CA248315, R01DK116005, R01CA174761, R01DK094004, R01DK127175
• NC
  National Cancer Institute

  Awards: R01CA228339, R01CA174761
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: R01DK116005, R01DK127175, R01DK094004