Opportunities and challenges in the diagnostic utility of dermal interstitial fluid

Friedel, Mark; Thompson, Ian A. P.; Kasting, Gerald B.; Polsky, Ronen; Cunningham, David D.; Soh, H. Tom; Heikenfeld, Jason

doi:10.1038/s41551-022-00998-9

reviewNature Biomedical EngineeringJan 19, 2023HYBRID OA

Opportunities and challenges in the diagnostic utility of dermal interstitial fluid

MFMark Friedel IAIan A. P. Thompson GBGerald B. Kasting RPRonen Polsky DDDavid D. Cunningham

University of Cincinnati · Stanford University · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The volume of interstitial fluid (ISF) in the human body is three times that of blood. Yet, collecting diagnostically useful ISF is more challenging than collecting blood because the extraction of dermal ISF disrupts the delicate balance of pressure between ISF, blood and lymph, and because the triggered local inflammation further skews the concentrations of many analytes in the extracted fluid. In this Perspective, we overview the most meaningful differences in the make-up of ISF and blood, and discuss why ISF cannot be viewed generally as a diagnostically useful proxy for blood. We also argue that continuous sensing of small-molecule analytes in dermal ISF via rapid assays compatible with nanolitre sample…

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Topics & keywords

Topics

Keywords

Interstitial fluid
Medicine
Tissue fluid
Immune system
Body fluid
Dermis
Pathology
Intensive care medicine

UN Sustainable Development Goals

Good health and well-being

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