Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles

The objective of this manuscript is to provide quantitative insights into the tissue distribution of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 different tissues of mice were collected from literature. A total of 2018 datasets were analyzed and biodistribution of graphene oxide, lipid, polymeric, silica, iron oxide and gold nanoparticles in different tissues was quantitatively characterized using Nanoparticle Biodistribution Coefficients (NBC). It was observed that typically after intravenous administration most of the nanoparticles are accumulated in the liver (NBC = 17.56 %ID/g) and spleen (NBC = 12.1 %ID/g), while other tissues received less than 5 %ID/g. NBC values…

• NC
  National Cancer Institute

  Awards: R01CA246785, R01CA256928
• NI
  National Institute of General Medical Sciences

  Award: GM114179
• NI
  National Institute of Allergy and Infectious Diseases
• DO
  Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

  Award: AI138195