reviewThe Journal of Infectious DiseasesJan 18, 2023HYBRID OA

Underascertainment of Respiratory Syncytial Virus Infection in Adults Due to Diagnostic Testing Limitations: A Systematic Literature Review and Meta-analysis

COChukwuemeka OnwuchekwaLMLaura Mora MoreoSMSonia MenonBMBelen MachadoDCDaniel Curcio

Pfizer (Ireland) · University of Edinburgh · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Background

Most observational population-based studies identify respiratory syncytial virus (RSV) by nasal/nasopharyngeal swab reverse transcriptase real-time PCR (RT-PCR) only. We conducted a systematic review and meta-analyses to quantify specimen and diagnostic testing-based underascertainment of adult RSV infection.

Methods

EMBASE, PubMed, and Web of Science were searched (January 2000-December 2021) for studies including adults using/comparing >1 RSV testing approach. We quantified test performance and RSV detection increase associated with using multiple specimen types.

Citation impact

181
total citations
FWCI
36.72
Percentile
100%
References
51
Citations per year

Authors

16

Topics & keywords

Topics
Keywords
  • Meta-analysis
  • Medicine
  • Virology
  • Virus
  • Respiratory system
  • Systematic review
  • Intensive care medicine
  • MEDLINE
UN Sustainable Development Goals
  • Good health and well-being
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Funding