Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration

The structure of connective tissues including cartilage, tendons, and ligaments as well as many organs, like the skin, heart, liver, kidney, lungs, blood vessels, and bones, depend on collagen. The bulk of the network of structural proteins that make up the extracellular matrix of the heart is composed of collagen type I and type III, which provide structural support for the muscle cells and are crucial for cardiac function. The prognosis and progression of a disease or diseased state may be significantly impacted by the upregulation or downregulation of the collagen types, particularly Col I and Col III. For example, increasing Col I protein levels may impose increasing myocardial stiffness, impairing the…

• NI
  National Institutes of Health

  Awards: R01HL147662, R01 HL144125
• NH
  National Heart, Lung, and Blood Institute

  Award: R01 HL144125