A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation

•The number of patients with at least one Clavien ≥III complication was not significantly different between groups.•Severe post-transplant complications (Clavien grade IIIb or more), occurred less frequently in the HOPE-group.•This was caused by a 3.7-fold lower number of liver-related Clavien ≥IIIb complications per patient in the HOPE-group.•Graft failure due to liver-related complications did not occur in the HOPE-group but occurred in 7% in the control-group. Background & AimsMachine perfusion is a novel method intended to optimize livers before transplantation. However, its effect on morbidity within a 1-year period after transplantation has remained unclear.MethodsIn this multicenter controlled trial, we…

• NS
  National Science Foundation
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Awards: 32003B_153012, 33IC30_166909