Future Antimicrobials: Natural and Functionalized Phenolics

With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a…

• MC
  Ministerul Cercetării, Inovării şi Digitalizării
• UE
  Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii

  Awards: PN-III-P2-2, PN-III-P2-2.1-PED-2021-4380, PN-III-P2-2.1-PED-2021
• CC
  Colegiul Consultativ pentru Cercetare-Dezvoltare şi Inovare