A natural biological adhesive from snail mucus for wound repair
Kunming Institute of Botany · Chinese Academy of Sciences · +2 more institutions
Abstract
The discovery of natural adhesion phenomena and mechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the…
Citation impact
- FWCI
- 78.87
- Percentile
- 100%
- References
- 63
Authors
13- TDTuo DengCorresponding
Kunming Institute of Botany, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- DGDongxiu Gao
Kunming Institute of Botany, Chinese Academy of Sciences, State Ethnic Affairs Commission
- XSXuemei Song
Kunming Institute of Botany, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- ZZZhipeng Zhou
Kunming Institute of Botany, Chinese Academy of Sciences
- LZLixiao Zhou
Kunming Institute of Botany, Chinese Academy of Sciences, State Ethnic Affairs Commission
Topics & keywords
- Mucus
- Wound healing
- Biocompatibility
- Glycosaminoglycan
- Angiogenesis
- Adhesive
- Biomaterial
- Scaffold