reviewFrontiers in PharmacologyJan 24, 2023GOLD OA

Understanding the role of the gut microbiome in gastrointestinal cancer: A review

Gazi University · MSD (Italy) · +7 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Gastrointestinal cancer represents one of the most diagnosed types of cancer. Cancer is a genetic and multifactorial disease, influenced by the host and environmental factors. It has been stated that 20% of cancer is caused by microorganisms such as Helicobacter pylori , hepatitis B and C virus, and human papillomavirus. In addition to these well-known microorganisms associated with cancer, it has been shown differences in the composition of the microbiota between healthy individuals and cancer patients. Some studies have suggested the existence of the selected microorganisms and their metabolites that can promote or inhibit tumorigenesis via some mechanisms. Recent findings have shown that gut microbiome and…

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181
total citations
FWCI
26.31
Percentile
100%
References
218
Citations per year

Authors

11

Topics & keywords

Keywords
  • Microbiome
  • Cancer
  • Gastrointestinal cancer
  • Disease
  • Colorectal cancer
  • Carcinogenesis
  • Gut microbiome
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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