articleGutJan 27, 2023HYBRID OA

Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

CCClaire ConcheFFFabian FinkelmeierMPMarina PešićAMAdele M. NicolasTWTim W. Böttger

Goethe University Frankfurt · Georg Speyer Haus · +7 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically altered in murine models for hepatocellular carcinoma (HCC) and colorectal cancer (CRC) to analyse the effect of ferroptosis on tumour cells and the immune tumour microenvironment. The findings served as foundation for the identification of additional targets for combine therapy with ferroptotic inducer in the treatment of HCC and liver metastasis. Results Surprisingly, hepatocyte-restricted GPx4 loss does not suppress hepatocellular tumourigenesis. Instead,…

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240
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Authors

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Topics & keywords

Topics
Keywords
  • Cancer research
  • Immune system
  • Tumor microenvironment
  • Medicine
  • Immunology
  • Metastasis
  • Liver cancer
  • Immune checkpoint
UN Sustainable Development Goals
  • Good health and well-being
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