Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and…

• GO
  Government of Jiangsu Province
• V
  Vetenskapsrådet

  Award: 2021-05498
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20211545
• SU
  Soochow University

  Award: SDGH2202
• LF
  LEO Fondet

  Award: LF15007
• NI
  National Institutes of Health

  Award: AI134770
• MO
  Mission on Nano Science and Technology

  Award: SDGH2202
• NK
  National Key Research and Development Program of China

  Awards: 2020YFA0710700, 2022YFE0124000