The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

Alzheimer's disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of disease may lead to new, effective therapeutic strategies. Amyloid beta oligomers and plaques, tau aggregates, and neuroinflammation play a critical role in neurodegeneration and impact clinical AD progression. The upstream modulators of these pathological features have not been fully clarified, but recent evidence indicates that the gut microbiome (GMB) may have an influence on these features and therefore may influence AD progression in human patients. In this…

• NU
  Northwestern University

  Award: T32GM008152
• OP
  Open Philanthropy Project
• GV
  Good Ventures Foundation

  Award: F30AG079577
• NI
  National Institute of General Medical Sciences

  Award: T32GM008152