reviewInternational Journal of Biological SciencesJan 1, 2023GOLD OA

An Overview: The Diversified Role of Mitochondria in Cancer Metabolism

YLYue LiuYSYihong SunYGYadong GuoXSXiaoyun ShiXCXi Chen

Shanghai Tenth People's Hospital · Tongji University · +6 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

/NADH to prevent metastasis and progression of cancers. In this review, we discussed mitochondrial function in cancer cell metabolism and specially explored the unique role of mitochondria in cancer stem cells and the tumor microenvironment. Targeting the OXPHOS pathway and mitochondria-related metabolism emerging as a potential therapeutic strategy for various cancers.

Citation impact

224
total citations
FWCI
52.16
Percentile
100%
References
306
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Mitochondrion
  • Oxidative phosphorylation
  • Biology
  • Cancer cell
  • Cell biology
  • Citric acid cycle
  • Glycolysis
  • Bioenergetics
UN Sustainable Development Goals
  • Affordable and clean energy
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