The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
Rega Institute for Medical Research · KU Leuven
Abstract
Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infection and tissue injury. CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2, the atypical chemokine receptor ACKR1, and glycosaminoglycans. Furthermore, (hetero)dimerization and tight regulation of transcription and translation, as well as post-translational modifications further fine-tune the spatial and temporal activity of CXCL8 in the context of inflammatory diseases and cancer. The CXCL8 interaction with…
Citation impact
- FWCI
- 119.19
- Percentile
- 100%
- References
- 347
Authors
3Topics & keywords
- Chemokine
- CXC chemokine receptors
- Chemokine receptor
- CXCL2
- Interleukin 8
- Chemotaxis
- Immunology
- Angiogenesis
- Good health and well-being