reviewInternational Journal of Molecular SciencesJan 31, 2023GOLD OA

CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease

RGRaquel Gómez-BrisÁSÁngela SaézBHBeatriz Herrero‐FernándezCRCristina RiusHSHector Sánchez-Martinez

Research Institute Hospital 12 de Octubre · Universidad Autónoma de Madrid · +5 more institutions

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Abstract

Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or ulcerative colitis (UC). IBD is characterized by exacerbated innate and adaptive immunity in the gut in association with microbiota dysbiosis and the disruption of the intestinal barrier, resulting in increased bacterial exposure. In response to signals from microorganisms and damaged tissue, innate immune cells produce inflammatory cytokines and factors that stimulate T and B cells of the adaptive immune system, and a prominent characteristic of IBD patients is the accumulation of inflammatory T-cells and their…

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219
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Authors

6

Topics & keywords

Topics
Keywords
  • Immunology
  • Immune system
  • Innate lymphoid cell
  • Acquired immune system
  • Proinflammatory cytokine
  • Inflammatory bowel disease
  • Biology
  • Dysbiosis
UN Sustainable Development Goals
  • Good health and well-being
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