Single-cell spatial immune landscapes of primary and metastatic brain tumours
McGill University · University of Toronto · +8 more institutions
Abstract
Abstract Single-cell technologies have enabled the characterization of the tumour microenvironment at unprecedented depth and have revealed vast cellular diversity among tumour cells and their niche. Anti-tumour immunity relies on cell–cell relationships within the tumour microenvironment 1,2 , yet many single-cell studies lack spatial context and rely on dissociated tissues 3 . Here we applied imaging mass cytometry to characterize the immunological landscape of 139 high-grade glioma and 46 brain metastasis tumours from patients. Single-cell analysis of more than 1.1 million cells across 389 high-dimensional histopathology images enabled the spatial resolution of immune lineages and activation states,…
Citation impact
- FWCI
- 105.79
- Percentile
- 100%
- References
- 66
Authors
28Topics & keywords
- Mass cytometry
- Immune system
- Biology
- Context (archaeology)
- Cell
- Glioma
- Cancer research
- Population